CURRICULUM VITAE
Anne Marie Hanneken, M.D.
Associate Professor
Department of Molecular and Experimental Medicine- SP201
The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, CA 92037
Clinical & Research Interests:
· Preservation of photoreceptor cell function in the setting of macular diseases.
· Improving visual sensitivity and synaptic transmission in macular degeneration patients.
· Neuroprotection for macular degeneration.
Professional Experience
2002-present Associate Professor, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA
1990-present: Vitreoretinal Surgeon. San Diego Vitreoretinal Associates, Scripps Memorial Hospital, La Jolla, California
2000-2002: Associate Professor, Department of Cell Biology, The Scripps Research Institute,
La Jolla, California
1994-2000: Assistant Professor, Department of Cell Biology, The Scripps Research Institute, La Jolla, California
1990-1994: Assistant Member and Head of Eye Research, Department of Molecular and Cellular Growth Biology, The Whittier Institute for Diabetes and Endocrinology, La Jolla, California
1990-2000: Assistant Adjunct Professor of Ophthalmology, Duke University, Durham, North Carolina
Education
1990-1994 Postdoctoral Research Fellowship in the Department of Cell and Molecular Biology, The Scripps Whittier Institute for Diabetes and Endocrinology, La Jolla, California. Research Directors: Dr. Roger Guillemin, M.D., Nobel Laureate, and Andrew Baird, Ph.D.
1988-1990: Clinical Fellowship in Vitreoretinal Surgery, Duke University Eye Center, Durham, North Carolina
1985-1988: Residency in Ophthalmology – The Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, Maryland
1984-1985: Internship in Internal Medicine at Rush, Presbyterian, St. Luke’s Medical Center, Chicago, Illinois
1980-1984: M.D. degree, Medical College of Wisconsin, Milwaukee, Wisconsin
Advisory Boards
2005 Bausch & Lomb - Ocular Nutritional Global Advisory Board
2004-2005 Scripps Clinic & Green Hospital General Clinical Research Center (GCRC) Advisory Committee
Societies and Appointments
National Eye Institute (NEI/NIH) Reviewer
Member - Retina Society
Member - Vitreous Society
Member - Campo Society
Fellow of the American Academy of Ophthalmology
Ad Hoc Reviewer - American Journal of Ophthalmology
Ad Hoc Reviewer - Current Eye Research
National Eye Institute (NEI/NIH) Reviewer for Physician/Scientist Awards
Diplomat of the American Board of Ophthalmology - Board Certification (1989)
Member - Association for Research in Vision and Ophthalmology
Ad Hoc Reviewer - Investigative Ophthalmology and Visual Science
Member – California Medical Association
Member - San Diego Medical Society
Member- Heed Fellow’s Society
Former Member - The Association of Women Surgeons
Former Chair of the IRB Committee - The Whittier Institute for Diabetes & Endocrinology
Honors
1978: Phi Beta Kappa
Magna cum laude graduate
1988: Heed Foundation/Knapp Fellowship Award
1989: Hornaday Vitreoretinal Award, Duke Eye Center
Heed Foundation/Knapp Fellowship Award
BIBLIOGRAPHY
Book Chapters
1. McCuen, B.W., Goldbaum, M.H. and A. Hanneken. Chapter 11: Silicone Oil in the treatment of idiopathic macular holes. In: Macular Hole. S.A. Madreperla and B.W. McCuen II, eds. Butterworth-Heinemann, Woburn, MA 147-154, 1999.
Original Publications
1. Gallop, P., Flickinger, R., Hanneken, A., Minisohn, M. and Gabbay, K.. Chemical quantitation of hemoglobin glycosylation: Fluorometric detection of formaldehyde release upon periodate oxidation of glycoglobin. Anal. Biochem. 117:427-432, 1981.
2. Edelhauser, H.F., Hanneken, A., Pederson, H. and Van Horn, D.L. Osmotic tolerance of the rabbit and human corneal endothelium. Arch. Ophthalmol. 99:1281-1287, 1981.
3. Kucherlapati, R.S., Ayares, D., Hanneken, A., Noonan, K., Rauth, S., Spencer J.M., Wallace, L. and Moore, P.D. Homologous recombination in monkey cells and human cell-free extracts. Cold Spring Harb. Symp. Quant. Biol. 49: 191-7, 1984.
4. McCuen II, B.W., Goldbaum, M.H. and Hanneken, A.M. Silicone Oil in the Treatment of Idiopathic Macular Holes. IN: Macular Hole. Madreperla, S.A and B.W. McCuen II eds. pp. 147-154. Butterworth-Heinemann, Boston 1988.
5. Hanneken, A. and Michels, R.G. Vitrectomy and scleral buckling methods for proliferative vitreoretinopathy. Ophthalmology 95:865-869, 1988.
6. Jabs, D.A., Hanneken, A., Schachat, A.P. and Fine, S.L. Choroidopathy in systemic lupus erythematosis. Arch. Ophthalmol. 106:230-234, 1988.
7. Knox, D.L., Hanneken, A., Hollows, F.C., Miller, N.R., Schick, H.L. and Gonzales, W.L. Uremic optic neuropathy. Arch. Ophthalmol. 106:50-54, 1988.
8. Hanneken, A. and. Michels, R.G. Surgical treatment of proliferative vitreoretinopathy. In: Proliferative Vitreoretinopathy. H.M. Freeman and F.I. Tolentino (Eds.). New York, Springer-Verlag, 1988.
9. Hanneken, A., Miller, N.R., Debrun, G.M. and Nauta, H.J.W. Treatment of carotid-cavernous sinus fistulas using a detachable balloon catheter through the superior ophthalmic vein. Arch. Ophthalmol. 107:87-92, 1989.
10. Hanneken, A., Lutty, G.A., McLeod, D.S., Robey, F., Harvey, A.K. and Hjelmeland, L. Localization of basic fibroblast growth factor to the developing capillaries of the bovine retina. J. Cell. Physiol. 138:115-120, 1989.
11. Hanneken, A., de Juan Jr., E., Lutty, G.A., Fox, G.M., Schiffer, S. and Hjelmeland, L. Altered distribution of basic fibroblast growth factor in diabetic retinopathy. Arch. Ophthalmol. 109:1005-1011, 1991.
12. Hanneken, A., de Juan, Jr., E. and McCuen II, B.W. The management of retinal detachments associated with choroidal colobomas by vitreous surgery. Am. J. Ophthalmol. 111:271-275, 1991.
13. Hanneken, A. and Machemer, R. Ultrasonographic “Oil droplet phenomenon”. Arch. Ophthalmol. 109:320, 1991.
14. Hanneken, A. and Baird, A. Immunolocalization of basic fibroblast growth factor: Dependence on antibody type and tissue fixation. Exp. Eye Res. 54:1011-1014, 1992.
15. Hanneken, A., Ying, W., Ling, N. and Baird, A. Identification of soluble forms of the fibroblast growth factor in blood. Proc. Natl. Acad. Sci. USA 91: 9170-9174, 1994.
16. Hanneken, A. and Baird, A. Soluble forms of the high-affinity fibroblast growth factor receptor in human vitreous fluid. Invest. Ophthalmol. Vis. Sci. 36: 1192-1196, 1995.
17. Hanneken, A., Maher, P.A. and Baird, A. High affinity FGF receptors in the extracellular matrix of vascular endothelial cells: Implications for the modulation of FGF-2. J. Cell Biol., 128: 1221-1228, 1995.
18. Hanneken, A., Frautschy, S., Galasko, D. and Baird, A. A fibroblast growth factor binding protein in human cerebral spinal fluid. NeuroReports, 6: 886-888, 1995.
19. De Iongh, R., Lovicu, F., Hanneken, A., Baird, A., and McAvoy, J. FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth. Developmental Dynamics 206(4): 412-26,1996.
20. Goldbaum, M.H., McCuen, B.W., Hanneken, A.M., Burgess, S.K. and Chen H.H. Silicone oil tamponade to seal macular holes without position restrictions. Ophthalmology 105 (11): 2140-7, 1998.
21. Hanneken, A. Structural characterization of the soluble FGF receptors reveals multiple isoforms generated by secretion and ectodomain shedding. FEBS Letters, 489:176-181, 2001 (first published online 22 Dec 2000)
22. Maher, P. and Hanneken, A. The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line. Invest Ophthalmol Vis Sci. 46: 749-757, 2005.
23. Maher P. and Hanneken, A. Flavonoids protect retinal ganglion cells from oxidative stress-induced death. Invest Ophthalmol Vis Sci. V46: 4796-4803, 2005.
24. Hanneken, A, Lin, F., Johnson, J., Maher, P. and. Flavonoids protect human retinal pigment epithelial cells from oxidative stress-induced death. Invest Ophthalmol Vis Sci. 47: 3164-3177, 2006.
25. Maher, P. and Hanneken, A.M. Regulation of Neural Gene Transcription by Flavonoids. In: Polyphenols and Health: New and Recent Advances. Neville Vassallo eds. Nova Publishers, 2007.
26. Maher, P., Hanneken, A. Flavonoids protect retinal ganglion cells from ischemia in vitro. Experimental Eye Research, 86:366-374, 2008.
27. Hanneken, A., Maher, P. The efficacy of flavonoids in the protection of retinal pigment epithelial cells. AgroFOOD, 19:39-40, 2008.
28. Jennifer Johnson, Pamela Maher, and Hanneken, A. The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase II gene expression. Invest Ophthalmol Vis Sci 50(5):2398-406, 2009.
29. Hanneken, A., Harris, R., Olson, A. Crouch, R.K., Cornwall, C., Johnson, J.L., M. Kono. Modulation of opsin signaling by flavonoids. (manuscript in preparation)
30. Hanneken, A., Babia, N., Thoreson, W.B. Visual hallucinations in age-related macular degeneration patients are exacerbated by proton pump inhibitors: Clinical and electrophysiological studies. (manuscript in preparation)
31. Harris, R., Hanneken, A., Olson, A. Covalent Docking of All-trans Retinal to Rhodopsin Predicts Binding Interactions of the Metarhodopsin II and Metarhodopsin III States. (manuscript in preparation)
